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Proceedings Paper

Analytical solution to cone-beam SPECT reconstruction with non-uniform attenuation and distance-dependent resolution variation
Author(s): Hao Zhang; Junhai Wen; Jing Yang; Peng Hu; Zhengrong Liang
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Paper Abstract

Single photon emission computed tomography (SPECT) is a nuclear medicine imaging technique and widely used in the clinical applications. SPECT image reflects not only organizational structure but also functional activities of human body, such as blood-flow and metabolism condition, therefore diseases can be found much earlier. For many clinical applications, cone-beam geometry is preferred, which can improve count density and spatial resolution, and quantitative reconstruction of radiotracer distribution inside the body is desired. In this paper, we developed an efficient, analytical solution to cone-beam SPECT reconstruction with simultaneous compensation for attenuation and distance-dependent resolution variation (DDRV), as well as accurate treatment of Poisson noise. The simulation results show our reconstruction framework is feasible.

Paper Details

Date Published: 23 March 2010
PDF: 9 pages
Proc. SPIE 7622, Medical Imaging 2010: Physics of Medical Imaging, 762259 (23 March 2010); doi: 10.1117/12.843790
Show Author Affiliations
Hao Zhang, Beijing Institute of Technology (China)
Junhai Wen, Beijing Institute of Technology (China)
Jing Yang, Beijing Institute of Technology (China)
Peng Hu, Beijing Institute of Technology (China)
Zhengrong Liang, Stony Brook Univ. (United States)


Published in SPIE Proceedings Vol. 7622:
Medical Imaging 2010: Physics of Medical Imaging
Ehsan Samei; Norbert J. Pelc, Editor(s)

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