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Proceedings Paper

Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)
Author(s): Chao Zhou; Yihong Wang; Aaron D. Aguirre; Tsung-Han Tsai; David W. Cohen; James L. Connolly; James G. Fujimoto
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Paper Abstract

We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. Thirty four thyroid gland specimens were imaged from 17 patients, covering a spectrum of pathology, ranging from normal thyroid to neoplasia and benign disease. The integrated OCT and OCM imaging system allows seamlessly switching between low and high magnifications, in a way similar to traditional microscopy. Good correspondence was observed between optical images and histological sections. The results provide a basis for interpretation of future OCT and OCM images of the thyroid tissues and suggest the possibility of future in vivo evaluation of thyroid pathology.

Paper Details

Date Published: 20 February 2010
PDF: 8 pages
Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 755409 (20 February 2010); doi: 10.1117/12.843616
Show Author Affiliations
Chao Zhou, Massachusetts Institute of Technology (United States)
Yihong Wang, Beth Israel Deaconess Medical Ctr., Harvard Medical School (United States)
Montefiore Medical Ctr. and Albert Einstein Medical School (United States)
Aaron D. Aguirre, Massachusetts Institute of Technology (United States)
Harvard-MIT Division of Health Sciences and Technology (United States)
Tsung-Han Tsai, Massachusetts Institute of Technology (United States)
David W. Cohen, Beth Israel Deaconess Medical Ctr., Harvard Medical School (United States)
James L. Connolly, Beth Israel Deaconess Medical Ctr., Harvard Medical School (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 7554:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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