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Proceedings Paper

Molecular photoacoustic imaging using gold nanoparticles as a contrast agent
Author(s): Chulhong Kim; Eun Chul Cho; Jingyi Chen; Kwang Hyun Song; Leslie Au; Christopher P. Favazza; Qiang Zhang; Claire M. Cobley; Younan Xia; Lihong V. Wang
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Paper Abstract

Gold nanoparticles have received much attention due to their potential diagnostic and therapeutic applications. Gold nanoparticles are attractive in many biomedical applications because of their biocompatibility, easily modifiable surfaces for targeting, lack of heavy metal toxicity, wide range of sizes (35-100 nm), tunable plasmonic resonance peak, encapsulated site-specific drug delivery, and strong optical absorption in the near-infrared regime. Specifically, due to their strong optical absorption, gold nanoparticles have been used as a contrast agent for molecular photoacoustic (PA) imaging of tumor. The plasmonic resonance peak of the gold nanocages (AuNCs) was tuned to the near-infrared region, and the ratio of the absorption cross-section to the extinction cross-section was approximately ~70%, as measured by PA sensing. We used PEGylated gold nanocages (PEG-AuNCs) as a passive targeting contrast agent on melanomas. After 6-h intravenous injection of PEG-AuNCs, PA amplitude was increased by ~14 %. These results strongly suggest PA imaging paired with AuNCs is a promising diagnostic tool for early cancer detection.

Paper Details

Date Published: 26 February 2010
PDF: 5 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641V (26 February 2010); doi: 10.1117/12.843549
Show Author Affiliations
Chulhong Kim, Washington Univ. in St. Louis (United States)
Eun Chul Cho, Washington Univ. in St. Louis (United States)
Jingyi Chen, Washington Univ. in St. Louis (United States)
Kwang Hyun Song, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Leslie Au, Washington Univ. in St. Louis (United States)
Christopher P. Favazza, Washington Univ. in St. Louis (United States)
Qiang Zhang, Washington Univ. in St. Louis (United States)
Claire M. Cobley, Washington Univ. in St. Louis (United States)
Younan Xia, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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