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Proceedings Paper

Noninvasive detection of glucose concentration by differential absorption OCI with two wavelengths
Author(s): Yao Li; Yonghong He; Xiangsong Dai; Peng Li; Lian Duan; Yong Zhou; Nan Zeng
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Paper Abstract

We present a new method of glucose concentration detection with a differential absorption optical low-coherent interferometry (DAOCI) technique. In our system, we uses two OCI signals recorded by turns in one period with the same detector. Two different light sources are selected corresponding to the different absorption coefficient of the glucose absorption band. The ratio of the two intensities depends on the concentration of the glucose in samples. With the known difference in the absorption cross section or experimental data, it is possible to calculate the mean glucose concentration of samples. In our experiment, we measured a series of glucose solution in a cuvette, and the systemic resolution we got is 16.14mg/dL which achieves the required accuracy(20mg/dL) for practical application. The results prove the feasibility of this method to be used for no-invasive detection of glucose in the aqueous humor.

Paper Details

Date Published: 28 October 2009
PDF: 7 pages
Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 751911 (28 October 2009); doi: 10.1117/12.843457
Show Author Affiliations
Yao Li, Tsinghua Univ. (China)
Yonghong He, Tsinghua Univ. (China)
Xiangsong Dai, Tsinghua Univ. (China)
Peng Li, Tsinghua Univ. (China)
Lian Duan, Tsinghua Univ. (China)
Yong Zhou, Tsinghua Univ. (China)
Nan Zeng, Tsinghua Univ. (China)

Published in SPIE Proceedings Vol. 7519:
Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Pengcheng Li; Ling Fu, Editor(s)

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