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Proceedings Paper

Quantified characterization of dermal collagen structure in human cutaneous scars from second harmonic generation imaging
Author(s): Xiaoqin Zhu; Youting Chen; Shuangmu Zhuo; Biying Yu; Liqin Zheng; Kecheng Lu; Jianxin Chen
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Paper Abstract

In this paper, high resolution images of collagens based on second harmonic generation (SHG) were obtained in the dermis of different scar tissues and surrounding considered uninjured skins, demonstrating differences in their microstructures. In order to quantitatively analyze their structural features, Fourier analysis was applied for the SHG images to compare the alteration in collagen orientation of different scars. Moreover, depth dependant decay of SHG signals was also analyzed to provide more credible information. Our results show that the different types of scar tissues can be successfully distinguished with the two combined methods, which will help to determine the most appropriate clinical treatment strategy.

Paper Details

Date Published: 28 October 2009
PDF: 6 pages
Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75191B (28 October 2009); doi: 10.1117/12.843456
Show Author Affiliations
Xiaoqin Zhu, Fujian Normal Univ. (China)
Youting Chen, First Affiliated Hospital, Fujian Medical Univ. (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)
Biying Yu, Fujian Normal Univ. (China)
Liqin Zheng, Fujian Normal Univ. (China)
Kecheng Lu, Fujian Normal Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 7519:
Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Pengcheng Li; Ling Fu, Editor(s)

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