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Proceedings Paper

Registration of x-ray mammograms and three-dimensional speed of sound images of the female breast
Author(s): Torsten Hopp; Marie Holzapfel; Nicole V. Ruiter; Cuiping Li; Neb Duric
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Paper Abstract

Breast cancer is the most common type of cancer among women in Europe and North America. The established screening method to detect breast cancer is X-ray mammography, although X-ray frequently provides poor contrast for tumors located within glandular tissue. A new imaging approach is Ultrasound Tomography generating three-dimensional speed of sound images. This paper describes a method to evaluate the clinical applicability of three-dimensional speed of sound images by automatically registering the images with the corresponding X-ray mammograms. The challenge is that X-ray mammograms show two-dimensional projections of a deformed breast whereas speed of sound images render a three-dimensional undeformed breast in prone position. This conflict requires estimating the relation between deformed and undeformed breast and applying the deformation to the three-dimensional speed of sound image. The deformation is simulated based on a biomechanical model using the finite element method. After simulation of the compression, the contours of the X-ray mammogram and the projected speed of sound image overlap congruently. The quality of the matching process was evaluated by measuring the overlap of a lesion marked in both modalities. Using four test datasets, the evaluation of the registration resulted in an average tumor overlap of 97%. The developed registration provides a basis for systematic evaluation of the new modality of three-dimensional speed of sound images, e.g. allows a greater understanding of tumor depiction in these new images.

Paper Details

Date Published: 11 March 2010
PDF: 9 pages
Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 762905 (11 March 2010); doi: 10.1117/12.843454
Show Author Affiliations
Torsten Hopp, Karlsruhe Institute of Technology (Germany)
Marie Holzapfel, Karlsruhe Institute of Technology (Germany)
Nicole V. Ruiter, Karlsruhe Institute of Technology (Germany)
Cuiping Li, Karmanos Cancer Institute (United States)
Neb Duric, Karmanos Cancer Institute (United States)

Published in SPIE Proceedings Vol. 7629:
Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy
Jan D'hooge; Stephen A. McAleavey, Editor(s)

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