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Proceedings Paper

Pump-probe optical coherence microscopy
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Paper Abstract

High-resolution optical molecular imaging has become a vital tool for understanding and measuring physiologically important biometrics on the cellular and subcellular level. In spite of significant recent advances in microscopy, molecular imaging of most endogenous biomolecular species remains elusive. Directly imaging endogenous biomolecules without the aid of exogenous tags is highly desirable. We developed pump-probe optical coherence microscopy (PPOCM) based on our previous success in integrating pump-probe absorption spectroscopy with optical coherence tomography. A fixed human skin tissue with melanoma was imaged by the PPOCM system. The preliminary results show that PPOCM can provide better can clear contrast between normal tissue and melanoma than OCM. This system also can be used to image other chromophores.

Paper Details

Date Published: 19 February 2010
PDF: 4 pages
Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75541Z (19 February 2010); doi: 10.1117/12.843310
Show Author Affiliations
Qiujie Wan, Texas A&M Univ. (United States)
Brian E. Applegate, Texas A&M Univ. (United States)


Published in SPIE Proceedings Vol. 7554:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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