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Proceedings Paper

Development of carbon-fluorine spectroscopy for biopharmaceutical applications
Author(s): Farid Menaa; Bouzid Menaa; Carla Aiolfi Guimarães Menaa; Olga Sharts
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Paper Abstract

Carbon-Fluorine Spectroscopy (CFS), aka Fluoro-Raman Spectroscopy (FRS), is a patented platform technology using various methods and a family of devices called PLIRFATM (Pulsed Laser Isochronic Raman and Fluorescence Apparatus) developed by Fluorotronics, Inc. The key feature of this promising and flexible technology is based on the discovery of a characteristic optical signature of carbon-fluorine bond(s) in the fingerprint spectral area of 500 cm-1 and 950 cm-1 allowing detection, characterization, imaging, and measurement of fluoroorganics. The FRS method is ultra-specific, ultra-sensitive, non-destructive, rapid, require no sample preparation, easy to use and therefore, is cost effective. Furthermore, the C-F bond signal is directly proportional to the concentration of the analyte, allowing a quantitative determination of F-labelled compounds. Since the C-F bond is unique in its character, it can be used as an external or internal chemical tag/molecular marker. Furthermore, the C-F label is efficient, soluble, cheaper, smaller, more stable and less toxic than fluorescent dyes, nanoparticles or quantum dot materials. Consequently, FRS can be used for numerous applications. For instance, C-F bonds are often incorporated into pharmaceutical, agrochemical and biological molecules as well as in polymers and nano-materials to achieve special properties (e.g. molecular stability, tracing a compound during the production or the synthesis cycle). FRS is applicable for multiplexing, high throughput analysis of any type of fluoroorganics regardless their physical state. In this study, we present some of our data and review the most important applications of our patented technology in the biopharmaceutical field.

Paper Details

Date Published:
PDF: 10 pages
Proc. SPIE 7574, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII, 75740T; doi: 10.1117/12.843280
Show Author Affiliations
Farid Menaa, Fluorotronics, Inc. (United States)
Bouzid Menaa, Fluorotronics, Inc. (United States)
Carla Aiolfi Guimarães Menaa, Fluorotronics, Inc. (United States)
Olga Sharts, Fluorotronics, Inc. (United States)

Published in SPIE Proceedings Vol. 7574:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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