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Proceedings Paper

Optimizing penetration depth, contrast, and resolution in 3D dermatologic OCT
Author(s): Alex Aneesh; Boris Považay; Bernd Hofer; Edward Z. Zhang; Catherine Kendall; Jan Laufer; Sergei Popov; Carl Glittenberg; Susanne Binder; Nicholas Stone; Paul C Beard; Wolfgang Drexler
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Paper Abstract

High speed, three-dimensional optical coherence tomography (3D OCT) at 800nm, 1060nm and 1300nm with approximately 4μm, 7μm and 6μm axial and less than 15μm transverse resolution is demonstrated to investigate the optimum wavelength region for in vivo human skin imaging in terms of contrast, dynamic range and penetration depth. 3D OCT at 1300nm provides deeper penetration, while images obtained at 800nm were better in terms of contrast and speckle noise. 1060nm region was a compromise between 800nm and 1300nm in terms of penetration depth and image contrast. Optimizing sensitivity, penetration and contrast enabled unprecedented visualization of micro-structural morphology underneath the glabrous skin, hairy skin and in scar tissue. Higher contrast obtained at 800 nm appears to be critical in the in vitro tumor study. A multimodal approach combining OCT and PA helped to obtain morphological as well as vascular information from deeper regions of skin.

Paper Details

Date Published: 19 February 2010
PDF: 6 pages
Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75540V (19 February 2010); doi: 10.1117/12.843243
Show Author Affiliations
Alex Aneesh, Cardiff Univ. (United Kingdom)
Boris Považay, Medical Univ. Vienna (Austria)
Bernd Hofer, Medical Univ. Vienna (Austria)
Edward Z. Zhang, Univ. College London (United Kingdom)
Catherine Kendall, Gloucestershire Hospital (United Kingdom)
Jan Laufer, Univ. College London (United Kingdom)
Sergei Popov, Imperial College (United Kingdom)
Carl Glittenberg, Ludwig Boltzmann Institute (Austria)
Susanne Binder, Ludwig Boltzmann Institute (Austria)
Nicholas Stone, Gloucestershire Hospital (United Kingdom)
Paul C Beard, Univ. College London (United Kingdom)
Wolfgang Drexler, Medical Univ. Vienna (Austria)
Cardiff Univ. (United Kingdom)


Published in SPIE Proceedings Vol. 7554:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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