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Proceedings Paper

A multimodal contrast agent for simultaneous magnetic resonance and optical imaging of small animal
Author(s): M. B. Unlu; Y. Lin; B. Grimmond; A. Sood; E. Uzgiris; O. Nalcioglu; G. Gulsen
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Paper Abstract

Our goal is to assess the feasibility of a bi-functional contrast agent that is intravenously injected to an R3230 induced small animal breast tumor model. The MR/optical contrast agent was produced by GE Global Research, NY, and it was available in one size, Dp20. We used a combined frequency domain diffuse optical tomography (DOT) and a 4T magnetic resonance (MR) scanner to simultaneously measure the kinetics of the contrast agent in vivo. Both systems detected the signal change in the tumor and the non-tumor region. MR measurements served as a gold standard to validate the optical kinetics. We present both MR and DOT dynamic curves as well as the reconstructed optical absorption map.

Paper Details

Date Published: 23 February 2010
PDF: 7 pages
Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570C (23 February 2010); doi: 10.1117/12.843240
Show Author Affiliations
M. B. Unlu, Univ. of California, Irvine (United States)
Boğaziçi Univ. (Turkey)
Y. Lin, Univ. of California, Irvine (United States)
B. Grimmond, GE Global Research Ctr. (United States)
A. Sood, GE Global Research Ctr. (United States)
E. Uzgiris, GE Global Research Ctr. (United States)
O. Nalcioglu, Univ. of California, Irvine (United States)
G. Gulsen, Univ. of California, Irvine (United States)

Published in SPIE Proceedings Vol. 7557:
Multimodal Biomedical Imaging V
Fred S. Azar; Xavier Intes, Editor(s)

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