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Proceedings Paper

Spectroscopic evaluation of photodynamic therapy of the intraperitoneal cavity
Author(s): Jarod C. Finlay; Julia L. Sandell; Timothy C. Zhu; Robert Lewis; Keith A. Cengel; Stephen M. Hahn
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Paper Abstract

We present the results of spectroscopic measurements of diffuse reflectance and fluorescence before and after photodynamic therapy of healthy canine peritoneal cavity. Animals were treated intra-operatively after iv injection of the benzoporphyrin derivative (BPD). The small bowel was treated using a uniform light field projected by a microlens-tipped fiber. The cavity was then filled with scattering medium and the remaining organs were treated using a moving diffuser. Diffuse reflectance and fluorescence measurements were made using a multi-fiber optical probe positioned on the surface of various tissues within the cavity before and after illumination. The measured data were analyzed to quantify hemoglobin concentration and oxygenation and sensitizer concentration.

Paper Details

Date Published: 2 March 2010
PDF: 7 pages
Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 755109 (2 March 2010); doi: 10.1117/12.843184
Show Author Affiliations
Jarod C. Finlay, Univ. of Pennsylvania (United States)
Julia L. Sandell, Univ. of Pennsylvania (United States)
Timothy C. Zhu, Univ. of Pennsylvania (United States)
Robert Lewis, Univ. of Pennsylvania (United States)
Keith A. Cengel, Univ. of Pennsylvania (United States)
Stephen M. Hahn, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 7551:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX
David H. Kessel, Editor(s)

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