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Proceedings Paper

In vivo multiphoton imaging of obstructive cholestasis in mice
Author(s): Feng-Chieh Li; Yu Yang Lee; Ling-Ling Chiou; Hsuan-Shu Lee; Chen-Yuan Dong
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Paper Abstract

Combining multiphoton microscopy with a newly designed hepatic imaging window, we acquired in vivo images of mice obstructive cholestasis. We observed that in mice with bile duct ligation, bile canaliculi failed to appear during the whole observation period over 100 minutes following carboxyfluorescein diacetate injection, whereas the fluorescence was retained much longer within sinusoids. Furthermore, the fluorescence intensities in sinusoids were persistently higher than in hepatocytes during the course.

Paper Details

Date Published: 26 February 2010
PDF: 4 pages
Proc. SPIE 7569, Multiphoton Microscopy in the Biomedical Sciences X, 75692C (26 February 2010); doi: 10.1117/12.843096
Show Author Affiliations
Feng-Chieh Li, National Taiwan Univ. (Taiwan)
Yu Yang Lee, National Taiwan Univ. (Taiwan)
Ling-Ling Chiou, National Taiwan Univ. College of Medicine (Taiwan)
Hsuan-Shu Lee, National Taiwan Univ. (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)


Published in SPIE Proceedings Vol. 7569:
Multiphoton Microscopy in the Biomedical Sciences X
Ammasi Periasamy; Peter T. C. So; Karsten König, Editor(s)

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