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Proceedings Paper

Treatment feasibility study of osteoporosis using minimal invasive laser needle system
Author(s): Dongyeon Kang; Chang-Yong Ko; Yeon-Hang Ryu; Sunwook Park; Han-Sung Kim; Byungjo Jung
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Paper Abstract

Although the mechanism of laser stimulation effect in bone has not completely understood, laser stimulation is recommended in the treatment of osteoporosis due to positive treatment efficacy. In this study, a minimal invasive laser needle system (MILNS) was developed using a fine hollow needle in order to stimulate directly bone site by guiding an optical fiber. In order to evaluate the MILNS as a treatment method, in-vivo animal experiment study was performed using osteopenic mice. Twelve virginal ICR mice were employed and divided two groups: SHAM-group and LASERgroup. SHARM-group was stimulated by only fine hollow needle and LASER-group by fine hollow needle combined with laser stimulation. All mice were served in-vivo micro-CT images before and after treatment. Three dimensional (3D) structural parameters and vBMD (volume bone mineral density, g/cm3) in the trabecular bone were measured. After 2 weeks of stimulation, the vBMD, BV/TV, Tb.Th and Tb.N in LASER-group were significantly higher than those in SHAM-group (p<0.05). Potentially, this study suggested that the MILNS might prevent the bone loss and maintains the bone mineral density of osteopenic mice.

Paper Details

Date Published: 3 March 2010
PDF: 6 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484C (3 March 2010); doi: 10.1117/12.843088
Show Author Affiliations
Dongyeon Kang, Yonsei Univ. (Korea, Republic of)
Chang-Yong Ko, Yonsei Univ. (Korea, Republic of)
Yeon-Hang Ryu, Yonsei Univ. (Korea, Republic of)
Sunwook Park, Yonsei Univ. (Korea, Republic of)
Han-Sung Kim, Yonsei Univ. (Korea, Republic of)
Institute of Medical Engineering, Yonsei Univ. (Korea, Republic of)
Byungjo Jung, Yonsei Univ. (Korea, Republic of)
Institute of Medical Engineering, Yonsei Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; E. Duco Jansen; Andreas Mandelis; Brian Jet-Fei Wong; Justus F. R. Ilgner; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Henry Hirschberg; Steen J. Madsen; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Reza S. Malek, Editor(s)

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