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Proceedings Paper

A treatment planning system for pleural PDT
Author(s): Julia Sandell; Chang Chang; Jarod C Finlay; Timothy C. Zhu
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Paper Abstract

Uniform light fluence distribution for patients undergoing photodynamic therapy (PDT) is critical to ensure predictable PDT outcome. However, common practice uses a point source to deliver light to the pleural cavity. To improve the uniformity of light fluence rate distribution, we have developed a treatment planning system using an infrared camera to track the movement of the point source. This study examines the light fluence (rate) delivered to chest phantom to simulate a patient undergoing pleural PDT. Fluence rate (mW/cm2) and cumulative fluence (J/cm2) was monitored at 7 different sites during the entire light treatment delivery. Isotropic detectors were used for in-vivo light dosimetry. Light fluence rate in the pleural cavity is also calculated using the diffusion approximation with a finite-element model. We have established a correlation between the light fluence rate distribution and the light fluence rate measured on the selected points based on a spherical cavity model. Integrating sphere theory is used to aid the calculation of light fluence rate on the surface of the sphere as well as inside tissue assuming uniform optical properties. The resulting treatment planning tool can be valuable as a clinical guideline for future pleural PDT treatment.

Paper Details

Date Published: 3 March 2010
PDF: 6 pages
Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 75510C (3 March 2010); doi: 10.1117/12.843044
Show Author Affiliations
Julia Sandell, Univ. of Pennsylvania School of Medicine (United States)
Chang Chang, Univ. of Pennsylvania School of Medicine (United States)
Jarod C Finlay, Univ. of Pennsylvania School of Medicine (United States)
Timothy C. Zhu, Univ. of Pennsylvania School of Medicine (United States)


Published in SPIE Proceedings Vol. 7551:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX
David H. Kessel, Editor(s)

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