Share Email Print
cover

Proceedings Paper

Can dendritic cells see light?
Author(s): Aaron C.-H. Chen; Ying-Ying Huang; Sulbha K. Sharma; Michael R. Hamblin
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field of immune response study, it is not known with any certainty whether light/laser is proinflammatory or anti-inflammatory. Increasingly in recent times dendritic cells have been found to play an important role in inflammation and the immunological response. In this study, we try to look at the impact of low level near infrared light (810-nm) on murine bone-marrow derived dendritic cells. Changes in surface markers, including MHC II, CD80 and CD11c and the secretion of interleukins induced by light may provide additional evidence to reveal the mystery of how light affects the maturation of dendritic cells as well how these light-induced mature dendritic cells would affect the activation of adaptive immune response.

Paper Details

Date Published: 25 February 2010
PDF: 7 pages
Proc. SPIE 7565, Biophotonics and Immune Responses V, 756504 (25 February 2010); doi: 10.1117/12.842959
Show Author Affiliations
Aaron C.-H. Chen, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Ying-Ying Huang, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Guangxi Medical Univ. (China)
Sulbha K. Sharma, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Michael R. Hamblin, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Harvard-MIT Division of Health Sciences and Technology (United States)


Published in SPIE Proceedings Vol. 7565:
Biophotonics and Immune Responses V
Wei R. Chen, Editor(s)

© SPIE. Terms of Use
Back to Top