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Proceedings Paper

In vivo measurement of skin blood microcirculation using diffusing wave correlation technique
Author(s): Igor Meglinski; Vyacheslav Kalchenko; Alon Harmelin
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Paper Abstract

We combine diffusing wave spectroscopy and dynamic light scattering microscopy to simultaneous non-invasive imaging of skin blood microcirculation. We demonstrate for the first time to our knowledge that the local blood micro-flows and blood microcirculation can be observed and analyzed quantitatively at the the biological zero, when the arterial and vein flows are stopped completely. We show that the biological zero signal arises from the local blood micro-flows observed postmortem up to 100 minutes. The high sensitivity of diffusing correlation technique and the feasibility for non-invasive measurement of skin blood microcirculation is thus demonstrated, and the potential for methodology can now be explored.

Paper Details

Date Published: 25 February 2010
PDF: 6 pages
Proc. SPIE 7563, Dynamics and Fluctuations in Biomedical Photonics VII, 75630F (25 February 2010); doi: 10.1117/12.842926
Show Author Affiliations
Igor Meglinski, Univ. of Otago (New Zealand)
Cranfield Univ. (United Kingdom)
Vyacheslav Kalchenko, Weizmann Institute of Science (Israel)
Alon Harmelin, Weizmann Institute of Science (Israel)

Published in SPIE Proceedings Vol. 7563:
Dynamics and Fluctuations in Biomedical Photonics VII
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin, Editor(s)

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