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Proceedings Paper

Gold nanoprobes for multi-modality tumor imaging
Author(s): James Nyagilo; Ming Xiao; Xiankai Sun; Digant P. Davé
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Paper Abstract

Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ~65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model.

Paper Details

Date Published: 1 March 2010
PDF: 4 pages
Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 75760X (1 March 2010); doi: 10.1117/12.842917
Show Author Affiliations
James Nyagilo, The Univ. of Texas at Arlington (United States)
The Univ. of Texas Southwestern Medical Ctr. (United States)
Ming Xiao, The Univ. of Texas Southwestern Medical Ctr. (United States)
Peking Univ. (China)
Xiankai Sun, The Univ. of Texas Southwestern Medical Ctr. (United States)
Digant P. Davé, The Univ. of Texas at Arlington (United States)
The Univ. of Texas Southwestern Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 7576:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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