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Proceedings Paper

Non-thermal ablation technology for arrhythmia therapy: acute and chronic electrical conduction block with photosensitization reaction
Author(s): Arisa Ito; Hiroki Matsuo; Tsukasa Suenari; Takuro Kajihara; Takehiro Kimura; Shunichiro Miyoshi; Tsunenori Arai
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Paper Abstract

We have examined the possibility of non-thermal ablation technology for arrhythmia therapy with photosensitization reaction, in which photochemically generated singlet molecular oxygen may induce myocardial electrical conduction block. In the most popular energy source for arrhythmia catheter ablation; radiofrequency current, the thermal tissue injury causes electrophysiological disruption resulting in electrical isolation of ectopic beats. The temperature-mediated tissue disruption is difficult to control because the tissue temperature is determined by the heating and thermal conduction process, so that severe complications due to excessive heat generation have been the problem in this ablation. We demonstrated the electrical conduction block of surgically exposed porcine heart tissue in vivo with photosensitization reaction. The acute myocardial electrical conduction block was examined by the stimulation and propagation set-up consisting of a stimulation electrode and two bipolar measurement electrodes. Fifteen to thirty minutes after the injection of 5-10 mg/kg water-soluble chlorine photosensitizer, Talaporfin sodium (NPe6, LS11), the laser light at the wavelength of 663 nm with the total energy density of 50-200 J/cm2 was irradiated several times with 3- 7 mm in spot-size to make electrical block line in myocardial tissue across the conduction pathway between the bipolar measurement electrodes. The propagation delay time of the potential waveform increased with increasing the irradiated line length. The observation of Azan-stained specimens in the irradiated area two weeks after the procedure showed that the normal tissue was replaced to the scar tissue, which might become to be permanent tissue insulation. These results demonstrated the possibility of non-thermal electrical conduction block for arrhythmia therapy by the photosensitization reaction.

Paper Details

Date Published: 2 March 2010
PDF: 7 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75483B (2 March 2010); doi: 10.1117/12.842896
Show Author Affiliations
Arisa Ito, Keio Univ. (Japan)
Hiroki Matsuo, Keio Univ. (Japan)
Tsukasa Suenari, Keio Univ. (Japan)
Takuro Kajihara, Keio Univ. (Japan)
Takehiro Kimura, Keio Univ. School of Medicine (Japan)
Shunichiro Miyoshi, Keio Univ. School of Medicine (Japan)
Tsunenori Arai, Keio Univ. (Japan)

Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Henry Hirschberg M.D.; Kenton W. Gregory M.D.; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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