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Proceedings Paper

Optoacoustic imaging of an animal model of prostate cancer
Author(s): Michelle P. Patterson; Michel Arsenault; Chris Riley D.V.M.; Michael Kolios; William M. Whelan
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Paper Abstract

Prostate cancer is currently the most common cancer among Canadian men. Due to an increase in public awareness and screening, prostate cancer is being detected at earlier stages and in much younger men. This is raising the need for better treatment monitoring approaches. Optoacoustic imaging is a new technique that involves exposing tissues to pulsed light and detecting the acoustic waves generated by the tissue. Optoacoustic images of a tumour bearing mouse and an agematched control were acquired for a 775 nm illumination using a reverse-mode imaging system. A murine model of prostate cancer, TRAMP (transgenetic adenocarcinoma of mouse prostate), was investigated. The results show an increase in optoacoustic signal generated by the tumour compared to that generated by the surrounding tissues with a contrast ratio of 3.5. The dimensions of the tumour in the optoacoustic image agreed with the true tumour dimensions to within 0.5 mm. In this study we show that there are detectable changes in optoacoustic signal strength that arise from the presence of a tumour in the prostate, which demonstrates the potential of optoacoustic imaging for the monitoring of prostate cancer therapy.

Paper Details

Date Published: 23 February 2010
PDF: 5 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641B (23 February 2010); doi: 10.1117/12.842873
Show Author Affiliations
Michelle P. Patterson, Univ. of Prince Edward Island (Canada)
Atlantic Veterinary College (Canada)
Michel Arsenault, Univ. of Prince Edward Island (Canada)
Chris Riley D.V.M., Atlantic Veterinary College (Canada)
Michael Kolios, Ryerson Univ. (Canada)
William M. Whelan, Univ. of Prince Edward Island (Canada)
Atlantic Veterinary College (Canada)

Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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