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Proceedings Paper

Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements
Author(s): Sarah Ruderman; Valentina Stoyneva; Andrew J. Gomes; Jeremy D. Rogers; Vadim Backman
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Paper Abstract

Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.

Paper Details

Date Published: 23 February 2010
PDF: 8 pages
Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560K (23 February 2010); doi: 10.1117/12.842857
Show Author Affiliations
Sarah Ruderman, Northwestern Univ. (United States)
Valentina Stoyneva, Northwestern Univ. (United States)
Andrew J. Gomes, Northwestern Univ. (United States)
Jeremy D. Rogers, Northwestern Univ. (United States)
Vadim Backman, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 7556:
Design and Quality for Biomedical Technologies III
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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