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Proceedings Paper

A hybrid fluorescence tomography and x-ray CT system for quantitative molecular imaging
Author(s): Yuting Lin; William C. Barber; Jan S. Iwanczk; Werner W. Roeck; Orhan Nalcioglu; Gultekin Gulsen
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Paper Abstract

A gantry-based hybrid fluorescence and x-ray computed tomography (FT/CT) system is developed for quantitative molecular imaging. The performance of the dual modality FT/CT system is evaluated using an irregular shaped phantom with an inclusion containing Indocyanine-Green (ICG). The anatomical data from CT provides structural a priori information for the FT inverse problem. Although a 4.2 mm diameter inclusion can be resolved in the reconstructed concentration image without any a priori information, ICG concentration in the inclusion is recovered with 75% error. On the other hand, the error in the recovered ICG concentration reduces to 15% when a priori information from CT is utilized. The results demonstrate that accurate fluorophore concentration can only be obtained when x-ray CT structural a priori information is available.

Paper Details

Date Published: 11 March 2010
PDF: 5 pages
Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570A (11 March 2010); doi: 10.1117/12.842773
Show Author Affiliations
Yuting Lin, Univ. of California, Irvine (United States)
William C. Barber, DxRay Inc. (United States)
Jan S. Iwanczk, DxRay Inc. (United States)
Werner W. Roeck, Univ. of California, Irvine (United States)
Orhan Nalcioglu, Univ. of California, Irvine (United States)
Gultekin Gulsen, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 7557:
Multimodal Biomedical Imaging V
Fred S. Azar; Xavier Intes, Editor(s)

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