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Proceedings Paper

Tumor PDT-associated immune response: relevance of sphingolipids
Author(s): Mladen Korbelik; Soroush Merchant; Duska M. Separovic
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Paper Abstract

Sphingolipids have become recognized as essential effector molecules in signal transduction with involvement in various aspects of cell function and death, immune response and cancer treatment response. Major representatives of sphingolipids family, ceramide, sphingosine and sphingosine-1-phosphate (S1P), have attracted interest in their relevance to tumor response to photodynamic therapy (PDT) because of their roles as enhancers of apoptosis, mediators of cell growth and vasculogenesis, and regulators of immune response. Our recent in vivo studies with mouse tumor models have confirmed that PDT treatment has a pronounced impact on sphingolipid profile in the targeted tumor and that significant advances in therapeutic gain with PDT can be attained by combining this modality with adjuvant treatment with ceramide analog LCL29.

Paper Details

Date Published: 11 February 2010
PDF: 7 pages
Proc. SPIE 7565, Biophotonics and Immune Responses V, 756502 (11 February 2010); doi: 10.1117/12.842760
Show Author Affiliations
Mladen Korbelik, British Columbia Cancer Agency (Canada)
Soroush Merchant, British Columbia Cancer Agency (Canada)
Duska M. Separovic, Wayne State Univ. (United States)

Published in SPIE Proceedings Vol. 7565:
Biophotonics and Immune Responses V
Wei R. Chen, Editor(s)

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