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Proceedings Paper

An optogenetic neural stimulation platform for concurrent induction and recording of neural activity
Author(s): Brian McGovern; Nir Grossman; Rolando Berlinguer-Palmini; Mark Neil; Emmanuel Drakakis; Patrick Degenaar
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Paper Abstract

The precise control of neural activity afforded by the use of light sensitive ion channels such as Channel Rhodopsin (ChR2) offers neuroscientists the means to devise new experiments. In this paper we present the Optogenetic Neural Stimulation (ONS) platform which enables complex in-vitro or ex-vivo investigation of neural activity. The platform is based on micro-meter sized Light Emitting Diodes (LEDs) integrated onto a single Gallium Nitrite chip. Mounted onto a microscope system, this system can be used to carry out experiments on networks of cells, or on sub-cellular regions of a neuron with millisecond timing and micrometer resolution.

Paper Details

Date Published: 3 March 2010
PDF: 8 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484X (3 March 2010); doi: 10.1117/12.842665
Show Author Affiliations
Brian McGovern, Institute of Biomedical Engineering, Imperial College London (United Kingdom)
Imperial College London (United Kingdom)
Nir Grossman, Imperial College London (United Kingdom)
Rolando Berlinguer-Palmini, Imperial College London (United Kingdom)
Mark Neil, Imperial College London (United Kingdom)
Emmanuel Drakakis, Imperial College London (United Kingdom)
Patrick Degenaar, Institute of Biomedical Engineering, Imperial College London (United Kingdom)
Imperial College London (United Kingdom)


Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong; Nikiforos Kollias; Henry Hirschberg; Kenton W. Gregory; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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