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Proceedings Paper

Development of a real-time closed-loop dual-wavelength optical polarimeter for glucose monitoring
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Paper Abstract

Over the last decade, noninvasive glucose sensors based on optical polarimetry have been proposed to probe the anterior chamber of the eye. Such sensors would ultimately be used to measure the aqueous humor glucose concentration which is correlated with blood glucose concentration. Although the effect of other chiral components in the eye has been minimized, the time-variant corneal birefringence due to motion artifact is still a limiting factor which needs to be resolved for realization of such a device. Here we present the development of a real-time dual wavelength optical polarimetric system employing a classical three-term feedback controller. Our dual wavelength system utilizes real-time closed-loop feedback based on proportional-integral-derivative (PID) control, which effectively reduced the time taken by the system to stabilize to less than 300 ms while minimizing the effect of motion artifact, which appears as common noise source for both wavelengths. Measurements in the presence of time-variant test cell birefringence demonstrate the sensitivity of the current system to measure glucose within the range of 0-600 mg/dl with a standard error of less than 13 mg/dl using the dual wavelength information.

Paper Details

Date Published: 17 February 2010
PDF: 5 pages
Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 757202 (17 February 2010); doi: 10.1117/12.842642
Show Author Affiliations
Bilal H. Malik, Texas A&M Univ. (United States)
Gerard L. Coté, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 7572:
Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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