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Proceedings Paper

Fast two-photon neuronal imaging and control using a spatial light modulator and ruthenium compounds
Author(s): Darcy S. Peterka; Volodymyr Nikolenko; Elodie Fino; Roberto Araya; Roberto Etchenique; Rafael Yuste
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Paper Abstract

We have developed a spatial light modulator (SLM) based microscope that uses diffraction to shape the incoming two-photon laser source to any arbitrary light pattern. This allows the simultaneous imaging or photostimulation of different regions of a sample with three-dimensional precision at high frame rates. Additionally, we have combined this microscope with a new class of two photon active neuromodulators with Ruthenium BiPyridine (RuBi) based cages that offer great flexibility for neuronal control.

Paper Details

Date Published: 3 March 2010
PDF: 9 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75484P (3 March 2010); doi: 10.1117/12.842606
Show Author Affiliations
Darcy S. Peterka, Howard Hughes Medical Institute, Columbia Univ. (United States)
Volodymyr Nikolenko, Howard Hughes Medical Institute, Columbia Univ. (United States)
Elodie Fino, Howard Hughes Medical Institute, Columbia Univ. (United States)
Roberto Araya, Howard Hughes Medical Institute, Columbia Univ. (United States)
Roberto Etchenique, Univ. de Buenos Aires (Argentina)
Rafael Yuste, Howard Hughes Medical Institute, Columbia Univ. (United States)


Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong; Nikiforos Kollias; Henry Hirschberg; Kenton W. Gregory; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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