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Proceedings Paper

Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow
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Paper Abstract

A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF). Since current non-invasive bedside methods can only indirectly assess blood flow, the goal of this research was to develop an optical technique for measuring absolute CBF. A time-resolved near-infrared (NIR) apparatus was built and its ability to accurately measure changes in optical properties was demonstrated in tissue-mimicking phantoms. The time-resolved system was combined with a bolus-tracking method for measuring CBF using the dye indocyanine green (ICG) as an intravascular flow tracer. Cerebral blood flow was measured in newborn piglets and for comparison, CBF was concurrently measured using a previously developed continuous-wave NIR method. Measurements were acquired with both techniques under three conditions: normocapnia, hypercapnia and following occlusion of the carotid arteries. Mean CBF values (N = 3) acquired with the TR-NIR system were 31.9 ± 11.7 ml/100g/min during occlusion, 39.7 ± 1.6 ml/100g/min at normocapnia, and 58.8 ± 9.9 ml/100g/min at hypercapnia. Results demonstrate that the developed TR-NIR technique has the sensitivity to measure changes in CBF; however, the CBF measurements were approximately 25% lower than the values obtained with the CW-NIRS technique.

Paper Details

Date Published: 22 February 2010
PDF: 9 pages
Proc. SPIE 7555, Advanced Biomedical and Clinical Diagnostic Systems VIII, 75550Z (22 February 2010); doi: 10.1117/12.842521
Show Author Affiliations
Mamadou Diop, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Kenneth M. Tichauer, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Jonathan T. Elliott, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Mark Migueis, Lawson Health Research Institute (Canada)
Ting-Yim Lee, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Keith St. Lawrence, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 7555:
Advanced Biomedical and Clinical Diagnostic Systems VIII
Tuan Vo-Dinh; Warren S. Grundfest; Anita Mahadevan-Jansen, Editor(s)

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