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Proceedings Paper

Limit of detection for a bead-based diffraction biosensor
Author(s): Youbong Lim; David D. Nolte; Khalid Arif; Cagri Savran
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Paper Abstract

Diffraction-based biosensors that rely on optical scattering are a sensitive approach for biomolecular detection. We present a Mie surface double-interaction computer study of the in situ assembly of bead-based diffraction gratings on a gold substrate. The limit of detection for a system having 26 stripes is calculated to be approximately 25 beads in total, or approximately one bead per stripe in an immunoassay experiment. This sensitivity limit is orders of magnitude better than label-free molecular sensors, and is consistent with high-speed scanning for high-throughput assays.

Paper Details

Date Published: 13 February 2010
PDF: 9 pages
Proc. SPIE 7574, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII, 75740W (13 February 2010); doi: 10.1117/12.842507
Show Author Affiliations
Youbong Lim, Purdue Univ. (United States)
David D. Nolte, Purdue Univ. (United States)
Khalid Arif, Birck Nanotechnology Ctr., Purdue Univ. (United States)
Cagri Savran, Birck Nanotechnology Ctr., Purdue Univ. (United States)


Published in SPIE Proceedings Vol. 7574:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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