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Proceedings Paper

Integration of photoacoustic, ultrasound, and magnetomotive system
Author(s): Congxian Jia; Sheng-Wen Huang; Yongdong Jin; Chi Hyung Seo; Lingyun Huang; Janet F. Eary; Xiaohu Gao; Matthew O'Donnell
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Paper Abstract

Ultrasonic (US) imaging is the most common real-time modality, providing multiple dimensional changes in morphology for clinical practice. Photoacoustic (PA) imaging has demonstrated great promise as a new functional and molecular imaging tool. However, absorption in background tissue also generates a PA signal and limits the specific contrast of molecular contrast agents. To increase the linear range of these agents, the background must be suppressed. Magnetic nanoparticles provide a new possibility to increase contrast by magnetomotive manipulation during imaging. A multi-functional imaging system integrating US and PA imaging with magnetic manipulation can take advantage of each single modality by providing anatomical images and molecular function with greater contrast. However, one key issue for multi-functional imaging is how to spatially combine and temporarily synchronize US and PA imaging with magnetomotive instrumentation. In this study, we built a simple system to integrate US and PA imaging with magnetomotive capability. We evaluated this system by measuring the motion of a phantom including magnetic nanoparticles (MNPs) using US when these particles were subjected to a time-varying magnetic field.

Paper Details

Date Published: 23 February 2010
PDF: 6 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756416 (23 February 2010); doi: 10.1117/12.842485
Show Author Affiliations
Congxian Jia, Univ. of Michigan (United States)
Sheng-Wen Huang, Univ. of Washington (United States)
Yongdong Jin, Univ. of Washington (United States)
Chi Hyung Seo, Univ. of Washington (United States)
Lingyun Huang, Univ. of Washington (United States)
Janet F. Eary, Univ. of Washington (United States)
Xiaohu Gao, Univ. of Washington (United States)
Matthew O'Donnell, Univ. of Michigan (United States)
Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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