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Proceedings Paper

Selective mucosal ablation using CO2 laser for the development of novel endoscopic submucosal dissection: comparison of continuous wave and nanosecond pulsed wave
Author(s): K. Ishii; S. Watanabe; D. Obata; H. Hazama; Y. Morita; Y. Matsuoka; H. Kutsumi; T. Azuma; K. Awazu
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Paper Abstract

Endoscopic submucosal dissection (ESD) is accepted as a minimally invasive treatment technique for small early gastric cancers. Procedures are carried out using some specialized electrosurgical knifes with a submucosal injection solution. However it is not widely used because its procedure is difficult. The objective of this study is to develop a novel ESD method which is safe in principle and widely used by using laser techniques. In this study, we used CO2 lasers with a wavelength of 10.6 μm for mucosal ablation. Two types of pulse, continuous wave and pulsed wave with a pulse width of 110 ns, were studied to compare their values. Porcine stomach tissues were used as a sample. Aqueous solution of sodium hyaluronate (MucoUpR) with 50 mg/ml sodium dihydrogenphosphate is injected to a submucosal layer. As a result, ablation effect by CO2 laser irradiation was stopped because submucosal injection solution completely absorbed CO2 laser energy in the invasive energy condition which perforates a muscle layer without submucosal injection solution. Mucosal ablation by the combination of CO2 Laser and a submucosal injection solution is a feasible technique for treating early gastric cancers safely because it provides a selective mucosal resection and less-invasive interaction to muscle layer.

Paper Details

Date Published: 11 February 2010
PDF: 5 pages
Proc. SPIE 7562, Optical Interactions with Tissues and Cells XXI, 75620Q (11 February 2010); doi: 10.1117/12.842426
Show Author Affiliations
K. Ishii, Osaka Univ. (Japan)
S. Watanabe, Osaka Univ. (Japan)
D. Obata, Kobe Univ. (Japan)
H. Hazama, Osaka Univ. (Japan)
Y. Morita, Kobe Univ. (Japan)
Y. Matsuoka, Kobe Univ. (Japan)
H. Kutsumi, Kobe Univ. (Japan)
T. Azuma, Kobe Univ. (Japan)
K. Awazu, Osaka Univ. (Japan)
Univ. of Fukui (Japan)


Published in SPIE Proceedings Vol. 7562:
Optical Interactions with Tissues and Cells XXI
E. Duco Jansen; Robert J. Thomas, Editor(s)

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