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Proceedings Paper

Imaging of mouse embryonic eye development using optical coherence tomography
Author(s): Saba H. Syed; Alyssa Kasiraj; Irina V. Larina; Mary E. Dickinson; Kirill V. Larin
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Paper Abstract

Congenital abnormalities are often caused by genetic disorders which alter the normal development of the eye. Embryonic eye imaging in mouse model is important for understanding of normal and abnormal eye development and can contribute to prevention and treatment of eye defects in humans. In this study, we used Swept Source Optical Coherence Tomography (SS-OCT) to image eye structure in mouse embryos at 12.5 to 17.5 days post coitus (dpc). The imaging depth of the OCT allowed us to visualize the whole eye globe at these stages. Different ocular tissues including lens, cornea, eyelids, and hyaloid vasculature were visualized. These results suggest that OCT imaging is a useful tool to study embryonic eye development in the mouse model.

Paper Details

Date Published: 2 March 2010
PDF: 5 pages
Proc. SPIE 7550, Ophthalmic Technologies XX, 75501A (2 March 2010); doi: 10.1117/12.842332
Show Author Affiliations
Saba H. Syed, Univ. of Houston (United States)
Alyssa Kasiraj, Univ. of Houston (United States)
Irina V. Larina, Baylor College of Medicine (United States)
Mary E. Dickinson, Baylor College of Medicine (United States)
Kirill V. Larin, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 7550:
Ophthalmic Technologies XX
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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