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Proceedings Paper

Homogeneous UVA system for corneal cross-linking treatment
Author(s): Fernando Ramon Ayres Pereira; Mario Antônio Stefani; José Antônio Otoboni; Eduardo Henrique Richter; Liliane Ventura
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Paper Abstract

The treatment of keratoconus and corneal ulcers by collagen cross-linking using ultraviolet type A irradiation, combined with photo-sensitizer Riboflavin (vitamin B2), is a promising technique. The standard protocol suggests instilling Riboflavin in the pre-scratched cornea every 5min for 30min, during the UVA irradiation of the cornea at 3mW/cm2 for 30 min. This process leads to an increase of the biomechanical strength of the cornea, stopping the progression, or sometimes, even reversing Keratoconus. The collagen cross-linking can be achieved by many methods, but the utilization of UVA light, for this purpose, is ideal because of its possibility of a homogeneous treatment leading to an equal result along the treated area. We have developed a system, to be clinically used for treatment of unhealthy corneas using the cross-linking technique, which consists of an UVA emitting delivery device controlled by a closed loop system with high homogeneity. The system is tunable and delivers 3-5 mW/cm2, at 365nm, for three spots (6mm, 8mm and 10mm in diameter). The electronics close loop presents 1% of precision, leading to an overall error, after the calibration, of less than 10% and approximately 96% of homogeneity.

Paper Details

Date Published: 23 February 2010
PDF: 9 pages
Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560Z (23 February 2010); doi: 10.1117/12.842260
Show Author Affiliations
Fernando Ramon Ayres Pereira, Opto Eletronica SA (Brazil)
Univ. of Sao Paulo (Brazil)
Mario Antônio Stefani, Opto Eletronica SA (Brazil)
José Antônio Otoboni, Opto Eletronica SA (Brazil)
Eduardo Henrique Richter, Opto Eletronica SA (Brazil)
Liliane Ventura, Univ. of Sao Paulo (Brazil)

Published in SPIE Proceedings Vol. 7556:
Design and Quality for Biomedical Technologies III
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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