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Proceedings Paper

Laser electrospray mass spectrometry of adsorbed molecules at atmospheric pressure
Author(s): John J. Brady; Elizabeth J. Judge; Kuriakose Simon; Robert J. Levis
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Paper Abstract

Atmospheric pressure mass analysis of solid phase biomolecules is performed using laser electrospray mass spectrometry (LEMS). A non-resonant femtosecond duration laser pulse vaporizes native samples at atmospheric pressure for subsequent electrospray ionization and transfer into a mass spectrometer. LEMS was used to detect a complex molecule (irinotecan HCl), a complex mixture (cold medicine formulation with active ingredients: acetaminophen, dextromethorphan HBr and doxylamine succinate), and a biological building block (deoxyguanosine) deposited on steel surfaces without a matrix molecule.

Paper Details

Date Published: 24 February 2010
PDF: 8 pages
Proc. SPIE 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII, 75680R (24 February 2010); doi: 10.1117/12.842217
Show Author Affiliations
John J. Brady, Temple Univ. (United States)
Elizabeth J. Judge, Temple Univ. (United States)
Kuriakose Simon, Temple Univ. (United States)
Robert J. Levis, Temple Univ. (United States)


Published in SPIE Proceedings Vol. 7568:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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