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Proceedings Paper

Healing and evaluating guinea pig skin incision after surgical suture and laser tissue by welding using in vivo Raman spectroscopy
Author(s): A. Alimova; V. Sriramoju; R. Chakraverty; R. Muthukattil; R. R. Alfano
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Paper Abstract

Changes in collagen in the wound during the healing process of guinea pig skin following surgical incisions and LTW was evaluated using in vivo, using Raman spectroscopy. Raman spectroscopy provided information regarding the internal structure of the proteins. After the incisions were closed either by suturing or by LTW the ratio of the Raman peaks of the amide III (1247 cm-1) band to a peak at 1326 cm-1 used to evaluate the progression of collagen deposition. Histopathology was used as the gold standard. LTW skin demonstrated better healing than sutured skin, exhibiting minimal hyperkeratosis, minimal collagen deposition, near-normal surface contour, and minimal loss of dermal appendages. This work is important to plastic surgery.

Paper Details

Date Published: 25 February 2010
PDF: 5 pages
Proc. SPIE 7561, Optical Biopsy VII, 756114 (25 February 2010); doi: 10.1117/12.842190
Show Author Affiliations
A. Alimova, The City College of New York (United States)
V. Sriramoju, The City College of New York (United States)
R. Chakraverty, The City College of New York (United States)
R. Muthukattil, The City College of New York (United States)
R. R. Alfano, The City College of New York (United States)


Published in SPIE Proceedings Vol. 7561:
Optical Biopsy VII
Robert R. Alfano, Editor(s)

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