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Proceedings Paper

Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography
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Paper Abstract

For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) non-invasively and in real time. The PAT system, based on a 512-element full-ring array with cylindrical focusing, received the PA signal primarily from a slice of about 2 mm thickness. This system can provide not only high resolution brain vasculature images but also hemodynamic functional images. We recorded the wash-in process of a photoacoustic contrast agent in a mouse brain in real time. Our results demonstrated that PAT is a powerful imaging modality to study real-time small animal neurofunctional activities that cause changes in hemodynamics.

Paper Details

Date Published: 23 February 2010
PDF: 5 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756427 (23 February 2010); doi: 10.1117/12.842159
Show Author Affiliations
Changhui Li, Washington Univ. in St. Louis (United States)
Andres Aquirre, Univ. of Connecticut (United States)
John Gamelin, Univ. of Connecticut (United States)
Anastasios Maurudis, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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