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Proceedings Paper

Pathological process investigation of Jadassohn-Pellizzari anetoderma based on multiphoton microscopy
Author(s): Jianxin Chen; Jingjun Zhao; Yinghong Yang; Shuangmu Zhuo; Xingshan Jiang; Wei Tian; Xiaoyin Ye; Lihang Lin
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Paper Abstract

Multiphoton microscopy based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) was firstly employed to investigate pathological process from the unaffected skin to the erythematous phase and to finally affected skin of Jadassohn-Pellizzari anetoderma. Our study showed that the normal elastic fibers in unaffected skin were almost completely absent in erthematous skin tissue, then replaced by a lot of elastic fibers with granular morphology in affected skin. The obvious change of collagen fibers and occurrence of inflammatory cell infiltration in erthematous tissue suggested that variation of these two components were also main pathogenesis of anetoderma except for deficiency of elastic fibers. Our results give a sight to noninvasively study the pathological process of skin disease and the other disease with tight relation to variation of collagen and elastic fibers in skin dermis and cell in skin epidermis.

Paper Details

Date Published: 29 October 2009
PDF: 4 pages
Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 751914 (29 October 2009); doi: 10.1117/12.841990
Show Author Affiliations
Jianxin Chen, Fujian Normal Univ. (China)
Jingjun Zhao, Affiliated Union Hospital, Fujian Medical Univ. (China)
Yinghong Yang, Affiliated Union Hospital, Fujian Medical Univ. (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)
Xingshan Jiang, Fujian Normal Univ. (China)
Wei Tian, Affiliated Union Hospital, Fujian Medical Univ. (China)
Xiaoyin Ye, Affiliated Union Hospital, Fujian Medical Univ. (China)
Lihang Lin, Affiliated Union Hospital, Fujian Medical Univ. (China)


Published in SPIE Proceedings Vol. 7519:
Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin; Pengcheng Li; Ling Fu, Editor(s)

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