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Proceedings Paper

Assessment of breast tumor margins via quantitative diffuse reflectance imaging
Author(s): J. Quincy Brown; Torre M. Bydlon; Stephanie A. Kennedy; Joseph Geradts; Lee G. Wilke; William Barry; Lisa M. Richards; Marlee K. Junker; Jennifer Gallagher; Nimmi Ramanujam
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Paper Abstract

A particular application of interest for tissue reflectance spectroscopy in the UV-Visible is intraoperative detection of residual cancer at the margins of excised breast tumors, which could prevent costly and unnecessary repeat surgeries. Our multi-disciplinary group has developed an optical imaging device, which is capable of surveying the entire specimen surface down to a depth of 1-2mm, all within a short time as required for intraoperative use. In an IRB-approved study, reflectance spectral images were acquired from 54 margins in 48 patients. Conversion of the spectral images to quantitative tissue parameter maps was facilitated by a fast scalable inverse Monte-Carlo model. Data from margin parameter images were reduced to image-descriptive scalar values and compared to gold-standard margin pathology. The utility of the device for classification of margins was determined via the use of a conditional inference tree modeling approach, and was assessed both as a function of type of disease present at the margin, as well as a function of distance of disease from the issue surface. Additionally, the influence of breast density on the diagnostic parameters, as well as the accuracy of the device, was evaluated.

Paper Details

Date Published: 26 February 2010
PDF: 7 pages
Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730O (26 February 2010); doi: 10.1117/12.841949
Show Author Affiliations
J. Quincy Brown, Duke Univ. (United States)
Torre M. Bydlon, Duke Univ. (United States)
Stephanie A. Kennedy, Duke Univ. (United States)
Joseph Geradts, Duke Univ. Medical Ctr. (United States)
Lee G. Wilke, Duke Univ. Medical Ctr. (United States)
William Barry, Duke Univ. Medical Ctr. (United States)
Lisa M. Richards, Duke Univ. (United States)
Marlee K. Junker, Duke Univ. (United States)
Jennifer Gallagher, Duke Univ. Medical Ctr. (United States)
Nimmi Ramanujam, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 7573:
Biomedical Applications of Light Scattering IV
Adam P. Wax; Vadim Backman, Editor(s)

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