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Proceedings Paper

Polymer-functionalised microspheres for immunosensing applications
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Paper Abstract

Homogeneous polymeric thin layers have been used as functionalising agents on silica microresonators in view of immunosensing applications. We have characterised the microspheres functionalised with poly-L-lactic acid and Eudragit® L100, as an alternative to the commonly used silanes. It is shown that after polymeric functionalization the quality factor of the silica microspheres remains around 107, and that the Q factor is still about 3x105 after chemical activation and covalent binding of immunogammaglobulin. This functionalising process of the microresonator constitutes a promising step towards the achievement of a highly sensitive immunosensor.

Paper Details

Date Published: 24 February 2010
PDF: 6 pages
Proc. SPIE 7559, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X, 75590W (24 February 2010); doi: 10.1117/12.841878
Show Author Affiliations
S. Soria, IFAC-CNR, Institute of Applied Physics (Italy)
Ctr. Studi e Ricerche (Italy)
F. Baldini, IFAC-CNR, Institute of Applied Physics (Italy)
S. Berneschi, IFAC-CNR, Institute of Applied Physics (Italy)
M. Brenci, IFAC-CNR, Institute of Applied Physics (Italy)
F. Cosi, IFAC-CNR, Institute of Applied Physics (Italy)
A. Giannetti, IFAC-CNR, Institute of Applied Physics (Italy)
G. Nunzi conti, IFAC-CNR, Institute of Applied Physics (Italy)
S. Pelli, IFAC-CNR, Institute of Applied Physics (Italy)
G. C. Righini, IFAC-CNR, Institute of Applied Physics (Italy)
B. Tiribilli, ISC-CNR, Institute of Complex Systems (Italy)


Published in SPIE Proceedings Vol. 7559:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications X
Israel Gannot, Editor(s)

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