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Proceedings Paper

Optical modulation of smooth muscle cell contraction
Author(s): Jonghee Yoon; Myunghwan Choi; Chulhee Choi
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Paper Abstract

Even though electrical stimulation is generally used for induction of smooth muscle cell contraction, it is very hard to obtain fine control and also very invasive for inserting electrodes. Herein, we developed a new optical technology to control smooth muscle cell contraction. This optical method using femtosecond pulsed laser (FSPL) has advantage of focused stimulation and fine control of stimulation intensity. Upon brief exposure to FSPL, smooth muscle cells showed a rapid increase of intracellular calcium levels followed by cell contraction. Collectively, we suggest that FSPL can be a useful tool for control of smooth muscle cell contraction.

Paper Details

Date Published: 25 February 2010
PDF: 5 pages
Proc. SPIE 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII, 75681X (25 February 2010); doi: 10.1117/12.841871
Show Author Affiliations
Jonghee Yoon, Korea Advanced Institute of Science and Technology (Korea, Republic of)
Myunghwan Choi, Korea Advanced Institute of Science and Technology (Korea, Republic of)
Chulhee Choi, Korea Advanced Institute of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 7568:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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