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Proceedings Paper

Optoacoustic 13C-breath test analyzer
Author(s): Hermann Harde; Günther Helmrich; Marcus Wolff
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Paper Abstract

The composition and concentration of exhaled volatile gases reflects the physical ability of a patient. Therefore, a breath analysis allows to recognize an infectious disease in an organ or even to identify a tumor. One of the most prominent breath tests is the 13C-urea-breath test, applied to ascertain the presence of the bacterium helicobacter pylori in the stomach wall as an indication of a gastric ulcer. In this contribution we present a new optical analyzer that employs a compact and simple set-up based on photoacoustic spectroscopy. It consists of two identical photoacoustic cells containing two breath samples, one taken before and one after capturing an isotope-marked substrate, where the most common isotope 12C is replaced to a large extent by 13C. The analyzer measures simultaneously the relative CO2 isotopologue concentrations in both samples by exciting the molecules on specially selected absorption lines with a semiconductor laser operating at a wavelength of 2.744 μm. For a reliable diagnosis changes of the 13CO2 concentration of 1% in the exhaled breath have to be detected at a concentration level of this isotope in the breath of about 500 ppm.

Paper Details

Date Published: 23 February 2010
PDF: 7 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641E (23 February 2010); doi: 10.1117/12.841660
Show Author Affiliations
Hermann Harde, Helmut-Schmidt Univ. (Germany)
Günther Helmrich, Helmut-Schmidt Univ. (Germany)
Marcus Wolff, Hamburg Univ. of Applied Sciences (Germany)


Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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