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Proceedings Paper

Synthesis and surface modification of highly fluorescent gold nanoclusters and their exploitation for cellular labeling
Author(s): Cheng-An J. Lin; Chih-Hsien Lee; Jiun-Tai Hsieh; Wan-Chun Yu; Hong-Zhi Yang; Jimmy K. Li; Ralph Sperling; Hsueh-Hsiao Wang; Hung-I Yeh; Wolfgang J. Parak; Walter H. Chang
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Paper Abstract

We introduce a general approach to make colorful fluorescent gold nanoclusters which are protected by dihydrolipoic acid, mercaptoundecanoic acid and polyethylenimine. The fluorescent gold nanoclusters can perform a variety of bioconjugation processes such as PEGylation, biotinylation as well as forming complex nanobioconjugates with streptavidins. The brightening effects under proper surface modification are also reported. The clusters have a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules. Nonspecific uptake by human aortic endothelial cells is demonstrated.

Paper Details

Date Published: 17 February 2010
PDF: 9 pages
Proc. SPIE 7575, Colloidal Quantum Dots for Biomedical Applications V, 757506 (17 February 2010); doi: 10.1117/12.841540
Show Author Affiliations
Cheng-An J. Lin, Chung Yuan Christian Univ. (Taiwan)
Ctr. for Nano Bioengineering, Chung Yuan Christian Univ. (Taiwan)
Chih-Hsien Lee, Chung Yuan Christian Univ. (Taiwan)
Ctr. for Nano Bioengineering, Chung Yuan Christian Univ. (Taiwan)
Jiun-Tai Hsieh, Chung Yuan Christian Univ. (Taiwan)
Ctr. for Nano Bioengineering, Chung Yuan Christian Univ. (Taiwan)
Wan-Chun Yu, Chung Yuan Christian Univ. (Taiwan)
Ctr. for Nano Bioengineering, Chung Yuan Christian Univ. (Taiwan)
Hong-Zhi Yang, Chung Yuan Christian Univ. (Taiwan)
Ctr. for Nano Bioengineering, Chung Yuan Christian Univ. (Taiwan)
Jimmy K. Li, National Univ. of Tainan (Taiwan)
Ralph Sperling, Philipps-Univ. Marburg (Germany)
Hsueh-Hsiao Wang, Mackay Memorial Hospital (Taiwan)
Hung-I Yeh, Mackay Memorial Hospital (Taiwan)
Wolfgang J. Parak, Philipps-Univ. Marburg (Germany)
Walter H. Chang, Chung Yuan Christian Univ. (Taiwan)
Ctr. for Nano Bioengineering, Chung Yuan Christian Univ. (Taiwan)


Published in SPIE Proceedings Vol. 7575:
Colloidal Quantum Dots for Biomedical Applications V
Marek Osinski; Wolfgang J. Parak; Thomas M. Jovin; Kenji Yamamoto, Editor(s)

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