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Proceedings Paper

Label-free optical control of arterial contraction
Author(s): Myunghwan Choi; Jonghee Yoon; Chulhee Choi
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Paper Abstract

Blood vessels, especially in the brain, dynamically change the diameters over time to provide sufficient blood supply where needed. At present, there is no technique that allows noninvasive control of vascular diameter in vivo. Here we report that label-free irradiation of femtosecond pulsed laser can trigger blood vessel contraction in vivo. In response to laser irradiation, cultured vascular smooth muscle cell showed a rapid increase in calcium concentration followed by the cell contraction. In a murine thinned skull window model, laser irradiation focused in the arterial vessel wall caused localized vascular contraction followed by recovery. Nonlinear nature of the pulsed laser allowed highly specific targeting of subcortical vessels without affecting the surrounding region. We propose that femtosecond pulsed laser irradiation will be a useful experimental tool in the field of vascular biology.

Paper Details

Date Published: 12 February 2010
PDF: 6 pages
Proc. SPIE 7562, Optical Interactions with Tissues and Cells XXI, 75620G (12 February 2010); doi: 10.1117/12.841505
Show Author Affiliations
Myunghwan Choi, Korea Advanced Institute of Science and Technology (Korea, Republic of)
Jonghee Yoon, Korea Advanced Institute of Science and Technology (Korea, Republic of)
Chulhee Choi, Korea Advanced Institute of Science and Technology (Korea, Republic of)


Published in SPIE Proceedings Vol. 7562:
Optical Interactions with Tissues and Cells XXI
E. Duco Jansen; Robert J. Thomas, Editor(s)

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