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Proceedings Paper

Enhanced detection of circulating melanoma cells using gold nanoparticles as photoacoustic contrasting agents
Author(s): Devin R. McCormack; Kiran Bhattacharyya; Raghuraman Kannan; Kattesh Katti; John A. Viator
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Paper Abstract

Nanotechnology and the various properties of gold nanoparticles (AuNPs) are quickly changing the field of cancer detection and treatment. Photoacoustic detection methods show an increase in sensitivity using gold nanoparticle antibody conjugation, which selectively targets melanoma cancer cells. Instead of targeting melanoma tumors, we tag single cells, analogous to circulating metastatic melanoma cells. Using an in vitro, stationary cell system and planar samples, we demonstrate an average of 24% improved optical detectability of melanoma cells tagged with AuNPs over unprocessed melanoma cells. Tagged cells showed a raised plateau of absorbance from 470nm to 550nm. Untagged cells showed a general decline in absorption as wavelength increased. The results of our study have the potential to not only better develop photoacoustic detection of melanoma, but also extend the viability and use of photoacoustics into detection of otherwise unpigmented cancers.

Paper Details

Date Published: 23 February 2010
PDF: 4 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756413 (23 February 2010); doi: 10.1117/12.841474
Show Author Affiliations
Devin R. McCormack, Univ. of Missouri, Columbia (United States)
Kiran Bhattacharyya, Univ. of Missouri, Columbia (United States)
Raghuraman Kannan, Univ. of Missouri, Columbia (United States)
Kattesh Katti, Univ. of Missouri, Columbia (United States)
John A. Viator, Univ. of Missouri, Columbia (United States)

Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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