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Proceedings Paper

Photoacoustic diagnosis of edema in rat burned skin
Author(s): Ken Yoshida; Shunichi Sato; Kosuke Hatanaka; Daizoh Saitoh; Hiroshi Ashida; Toshihisa Sakamoto; Minoru Obara
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Paper Abstract

Diagnosis of edema, abnormal accumulation of water in tissue, is important for managing various traumatic injuries and diseases. However, there is no established method for real-time, noninvasive monitoring of edema. In severe extensive burn injuries, edema develops both topically and systemically due to the increased permeability of blood vessels. In this study, we examined photoacoustic (PA) monitoring of edema formed in rat burn models. Deep dermal burn with a 20% total body surface area was made in the dorsal skin of rats. Burn and its adjacent nonburn tissues were irradiated with 6-ns light pulses at 1430 nm, which is one of the absorption peak wavelengths of water in the near infrared. The PA signal amplitude increased until 12 - 24 hr postburn, and thereafter it gradually decreased to its initial level; the latter phase (after 24 hr postburn) coincided with a diuretic phase in the rats. There was a significant correlation between the PA signal amplitudes and water contents in the tissue measured by wet/dry weight method. These findings demonstrate the validity of PA measurement for real-time, noninvasive monitoring of edema.

Paper Details

Date Published: 23 February 2010
PDF: 6 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75641C (23 February 2010); doi: 10.1117/12.841438
Show Author Affiliations
Ken Yoshida, Keio Univ. (Japan)
Shunichi Sato, National Defense Medical College Research Institute (Japan)
Kosuke Hatanaka, National Defense Medical College (Japan)
Daizoh Saitoh, National Defense Medical College Research Institute (Japan)
Hiroshi Ashida, National Defense Medical College Research Institute (Japan)
Toshihisa Sakamoto, National Defense Medical College (Japan)
Minoru Obara, Keio Univ. (Japan)


Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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