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Proceedings Paper

Synthesis of a dual contrast agent for ultrasound and photoacoustic imaging
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Paper Abstract

A dual contrast agent that combines perfluorocarbon droplets and metal nanoparticles has been developed for combined ultrasound and photoacoustic imaging. Metal nanoparticles were incorporated in dodecafluoropentane (DDFP) droplets encapsulated in a bovine serum albumin (BSA) shell. To embed aqueous colloidal suspensions of metal nanoparticles in DDFP, a phase transfer of the plasmonic nanoparticles was completed in two different strategies, a single and a double ligand exchange of capping materials. Emulsion techniques were used to encapsulate phase transferred metal nanoparticles within the DDFP droplets. Spectrophotometry and cryogenic transmission electron microscopy were used to characterize and to confirm successful fabrication of the dual contrast agent.

Paper Details

Date Published: 17 February 2010
PDF: 5 pages
Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 75760M (17 February 2010); doi: 10.1117/12.841431
Show Author Affiliations
Katheryne Wilson, The Univ. of Texas at Austin (United States)
Kimberly Homan, The Univ. of Texas at Austin (United States)
Stanislav Emelianov, The Univ. of Texas at Austin (United States)


Published in SPIE Proceedings Vol. 7576:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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