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Proceedings Paper

High anisotropy utilized diffuse light suppression for large area spectroscopic imaging
Author(s): Zhengbin Xu; Jingjing Liu; Young L. Kim
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Paper Abstract

A unique optical property of biological tissue is high anisotropy so that light is scattered in the same direction with respect to the incident direction. We demonstrate that simple back-directional gating allows us to take advantage of such an intrinsic property of biological tissue to significantly suppress unwanted diffuse light. In back-directional gated imaging, the high anisotropic property of the surrounding medium can serve as a waveguide in a moderate depth. Although this idea is straightforward, it has not been utilized for diffuse light suppression and imaging quality improvement such as contrast and resolution in large-area imaging for biological tissue. We further show that by combining a spectral analysis with back-directional gated imaging, image contrast and depth can be dramatically enhanced for visualizing stromal microvascular blood content in a relatively large area. Because microvasculature can be heterogeneous, our imaging approach can permit detailed visualization of microvascularity in a relatively large area up to ~20 mm x 20 mm.

Paper Details

Date Published: 26 February 2010
PDF: 7 pages
Proc. SPIE 7573, Biomedical Applications of Light Scattering IV, 75730W (26 February 2010); doi: 10.1117/12.841390
Show Author Affiliations
Zhengbin Xu, Purdue Univ. (United States)
Jingjing Liu, Purdue Univ. (United States)
Young L. Kim, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 7573:
Biomedical Applications of Light Scattering IV
Adam P. Wax; Vadim Backman, Editor(s)

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