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Proceedings Paper

Development of an autofluorescent probe designed to help brain tumor removal: study on an animal model
Author(s): R. Siebert; B. Leh; Y. Charon; M. Collado-Hilly; M.-A. Duval; L. Menard; F. P. Monnet; P. Varlet
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Paper Abstract

The complete resection of the brain tumour is crucial to the patient life quality and prognosis. An autofluorescence probe aiming at helping the surgeon to improve the completeness of the removal is being developed. Autofluorescence spectroscopy is a promising approach to define whether the tissue is cancerous or not. First ex vivo measurements have been realised on an animal model. After tumorous cell injection in rat brain, autofluorescence intensity is revealed from the extracted brain. These autofluorescence data are compared to results from a histological analysis of same brains. First indicators are identified that may have the ability to differentiate tumorous and healthy tissues.

Paper Details

Date Published: 2 March 2010
PDF: 8 pages
Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75483Y (2 March 2010); doi: 10.1117/12.841373
Show Author Affiliations
R. Siebert, Lab. IMNC, CNRS, Univ. Paris-Sud 11 (France)
B. Leh, Lab. IMNC, CNRS, Univ. Paris-Sud 11 (France)
Y. Charon, Lab. IMNC, CNRS, Univ. Paris-Sud 11 (France)
Univ. Paris 7 (France)
M. Collado-Hilly, INSERM (France)
M.-A. Duval, Lab. IMNC, CNRS, Univ. Paris-Sud 11 (France)
Univ. d'Evry (France)
L. Menard, Lab. IMNC, CNRS, Univ. Paris-Sud 11 (France)
Univ. Paris 7 (France)
F. P. Monnet, INSERM (France)
P. Varlet, Hôpital Sainte Anne (France)

Published in SPIE Proceedings Vol. 7548:
Photonic Therapeutics and Diagnostics VI
Anita Mahadevan-Jansen; Andreas Mandelis; Brian Jet-Fei Wong; Nikiforos Kollias; Henry Hirschberg; Kenton W. Gregory; Reza S. Malek; E. Duco Jansen; Guillermo J. Tearney; Steen J. Madsen; Bernard Choi; Justus F. R. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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