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Proceedings Paper

In vivo early detection of smoke-induced airway injury using 3-dimensional swept source optical coherence tomography
Author(s): Jiechen Yin; Gangjun Liu; Jun Zhang; Lingfeng Yu; Sari Mahon; David Mukai; Matthew Brenner; Zhongping Chen
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Paper Abstract

We report on the feasibility of rapid, high resolution, 3-dimensional swept source optical coherence tomography (3D SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system (MEMS) motor based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames per second are achieved by adopting the technique of shared-memory parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. We demonstrate the ability of the SSOCT system to detect increases in tracheal and bronchial airway thickness that occurs shortly after smoke exposure.

Paper Details

Date Published: 19 February 2010
PDF: 4 pages
Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 755408 (19 February 2010); doi: 10.1117/12.841346
Show Author Affiliations
Jiechen Yin, Univ. of California, Irvine (United States)
Gangjun Liu, Beckman Laser Institute (United States)
Jun Zhang, Beckman Laser Institute (United States)
Lingfeng Yu, Beckman Laser Institute (United States)
Sari Mahon, Beckman Laser Institute (United States)
David Mukai, Beckman Laser Institute (United States)
Matthew Brenner, Beckman Laser Institute (United States)
Univ. of California, Irvine (United States)
Zhongping Chen, Univ. of California, Irvine (United States)
Beckman Laser Institute (United States)


Published in SPIE Proceedings Vol. 7554:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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