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Proceedings Paper

Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model
Author(s): Song Hu; Sunday Oladipupo; Junjie Yao; Andrea C. Santeford; Konstantin Maslov; Joanna Kovalski; Jeffrey M. Arbeit; Lihong V. Wang
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Paper Abstract

A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance.

Paper Details

Date Published: 23 February 2010
PDF: 5 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756406 (23 February 2010); doi: 10.1117/12.841177
Show Author Affiliations
Song Hu, Washington Univ. in St. Louis (United States)
Sunday Oladipupo, Washington Univ. School of Medicine (United States)
Junjie Yao, Washington Univ. in St. Louis (United States)
Andrea C. Santeford, Washington Univ. School of Medicine (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Joanna Kovalski, Washington Univ. School of Medicine (United States)
Jeffrey M. Arbeit, Washington Univ. School of Medicine (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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