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Proceedings Paper

Developing multifunctional tissue simulating phantoms for quantitative biomedical optical imaging
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Paper Abstract

Many advantages of biomedical optical imaging modalities include low cost, portability, no radiation hazard, molecular sensitivity, and real-time non-invasive measurements of multiple tissue parameters. However, clinical acceptance of optical imaging is hampered by the lack of calibration standards and validation techniques. In this context, developing phantoms that simulate tissue structural, functional, and molecular properties is important for reliable performance and successful translation of biomedical optical imaging techniques to clinical applications. Over the years, we have developed various tissue simulating phantoms to validate imaging algorithms, to optimize instrument performance, to test contrast agents, and to calibrate acquisition systems. We also developed phantoms with multimodal contrasts for co-registration between different imaging modalities. In order to study tissue dynamic changes during medical intervention, we develop gel wax phantoms to simulate tissue optical and mechanical dynamics in response to compression load. We also dispersed heat sensitive microbubbles in agar agar gel phantoms to simulate heatinduced tissue coagulative necrosis in a cancer ablation procedure. The phantom systems developed in our lab have the potential to provide standardized traceable tools for multimodal imaging and image-guided intervention.

Paper Details

Date Published: 25 February 2010
PDF: 6 pages
Proc. SPIE 7567, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue II, 75670K (25 February 2010); doi: 10.1117/12.841162
Show Author Affiliations
Ronald Xu, The Ohio State Univ. (United States)
Jeff Xu, The Ohio State Univ. (United States)
Ruogu Qin, The Ohio State Univ. (United States)
Jiwei Huang, The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 7567:
Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue II
Robert J. Nordstrom, Editor(s)

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