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Proceedings Paper

Dynamic optical angiography of mouse anatomy using radial projections
Author(s): Richard B. Lam; Robert A. Kruger; Daniel R. Reinecke; Stephen P. DelRio; Michael M. Thornton; Paul A. Picot; Timothy G. Morgan
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Paper Abstract

We demonstrate the feasibility of optical angiography on live mice using a new photoacoustic computed tomography (PCT) scanner. The scanner uses a sparse array of discrete ultrasound detectors geometrically arranged to capture 128 simultaneous radial "projections" through a 25-mm-diameter volume of interest. Denser sets of interleaved radial projections are acquired by rotating the sparse array continuously about its vertical axis during data acquisition. The device has been designed specifically for imaging laboratory mice, which remain stationary during data collection. Angiographic data are acquired at a rate of 1280 radial projections per second following a bolus injection of 2 mg/mL of indocyanine green (ICG).

Paper Details

Date Published: 23 February 2010
PDF: 7 pages
Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756405 (23 February 2010); doi: 10.1117/12.841024
Show Author Affiliations
Richard B. Lam, OptoSonics, Inc. (United States)
Robert A. Kruger, OptoSonics, Inc. (United States)
Daniel R. Reinecke, OptoSonics, Inc. (United States)
Stephen P. DelRio, OptoSonics, Inc. (United States)
Michael M. Thornton, Endra, Inc. (United States)
Paul A. Picot, Endra, Inc. (United States)
Timothy G. Morgan, Endra, Inc. (United States)


Published in SPIE Proceedings Vol. 7564:
Photons Plus Ultrasound: Imaging and Sensing 2010
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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